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1

In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist

Xavier Emonds-Alt, Jean-Daniel Doutremepuich, Michel Heaulme, Gervais Neliat, Vincent Santucci, Regis Steinberg, Pol Vilain, Daniel Bichon, Jean-Philippe Ducoux, Vincenzo Proietto, Didier Van Broeck,

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.00 MB

english, 1993

2

The use of platelet-rich plasma to treat chronic tendinopathies: A technical analysis

Kaux, Jean-François, Emonds-Alt, Thibault

Journal:

Year:

2017

Language:

english

File:

PDF, 561 KB

english, 2017

3

Understanding chemical interaction between phosphonate-derivative molecules and silver surface cluster in SERS: a combined experimental and computational approach

Emonds-Alt, Gauthier, Mignolet, Benoit, Malherbe, Cedric, Monbaliu, Jean-Christophe M, Remacle, Francoise, Eppe, Gauthier

Journal:

Physical Chemistry Chemical Physics

Year:

2019

Language:

english

File:

PDF, 1.80 MB

english, 2019

4

Transforming growth factor type beta 1 (TGF-β1) down-regulates interleukin-2 production and up-regulates interleukin-2 receptor expression in a thymoma cell line

Arnaud Dupuy D'Angeac, Jacques Dornand, Xavier Emonds-Alt, Pierre Jullien, Jose A. Garcia-Sanz, François Erard

Journal:

Journal of Cellular Physiology

Year:

1991

Language:

english

File:

PDF, 1.05 MB

english, 1991

5

Effects of Capsaicin, (±)-CP-96,345 and SR 48968 on the Bradykinin-induced Airways Microvascular Leakage in Guinea-pigs

Y. Qian, X. Emonds-Alt, C. Advenier

Journal:

Pulmonary Pharmacology

Year:

1993

File:

PDF, 259 KB

1993

6

Tachykinin Receptor Antagonists and Cough

C. Advenier, X. Emonds-Alt

Journal:

Pulmonary Pharmacology

Year:

1996

Language:

english

File:

PDF, 201 KB

english, 1996

7

Electric birefringence of DNA and chromatin: Influence of divalent cations

Xavier Emonds-Alt, Claude Houssier, Eugène Fredericq

Journal:

Biophysical Chemistry

Year:

1979

Language:

english

File:

PDF, 1.40 MB

english, 1979

8

Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: Characterization of novel tachykinin receptor antagonists

J.-M. Derocq, M. Ségui, C. Blazy, X. Emonds-Alt, G. Le Fur, J.-C. Brelière, P. Casellas

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 362 KB

english, 1997

9

Pharmacological profile and chemical synthesis of SR 48968, a non-peptide antagonist of the neurokinin A (NK2) receptor

Xavier Emonds-Alt, Vincenzo Proietto, Didier Van Broeck, Pol Vilain, Charles Advenier, Gervais Neliat, Gérard Le Fur, Jean-Claude Brelère

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 359 KB

english, 1993

10

Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages

Boichot, Germain, Emonds-Alt, Advenier, Lagente

Journal:

Clinical & Experimental Allergy

Year:

1998

Language:

english

File:

PDF, 374 KB

english, 1998

11

SR 140333, a Novel, Selective, and Potent Nonpeptide Antagonist of the NK1 Tachykinin Receptor: Characterization on the U373MG Cell Line

F. Oury-Donat, I. A. Lefevre, O. Thurneyssen, T. Gauthier, A. Bordey, P. Feltz, X. Emonds-Alt, G. Le Fur, P. Soubrie

Journal:

Journal of Neurochemistry

Year:

1994

Language:

english

File:

PDF, 959 KB

english, 1994

12

Pharmacological Characterization of Tachykinin Receptors Controlling Acetylcholine Release from Rat Striatum: An In Vivo Microdialysis Study

R. Steinberg, D. Rodier, J. Souilhac, I. Bougault, X. Emonds-Alt, P. Soubrié, G. Le Fur

Journal:

Journal of Neurochemistry

Year:

1995

Language:

english

File:

PDF, 638 KB

english, 1995

13

Interactions of tachykinin receptor antagonists with lipopolysaccharide-induced airway inflammation in mice

M Veron, I Guenon, S Nenan, X Emonds-Alt, C Advenier, V Lagente, E Boichot

Journal:

Clinical and Experimental Pharmacology and Physiology

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

14

Role of tachykinins in castor oil diarrhoea in rats

Tiziano Croci, Marco Landi, Xavier Emonds-Alt, Gérard Le Fur, Jean-Pierre Maffrand, Luciano Manara

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 332 KB

english, 1997

15

In vitro characterization of tachykinin NK2-receptors modulating motor responses of human colonic muscle strips

Tiziano Croci, Giulio Aureggi, Luciano Manara, Xavier Emonds-Alt, Gerard Le Fur, Jean-Pierre Maffrand, Sylvain Mukenge, Gianfranco Ferla

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 522 KB

english, 1998

16

Neurokinin B- and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig

Samira Daoui, Emmanuel Naline, Vincent Lagente, Xavier Emonds-Alt, Charles Advenier

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 183 KB

english, 2000

17

Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells

X. Emonds-Alt, E. Quisquater, G. Vaes

Journal:

European Journal of Cancer (1965)

Year:

1965

Language:

english

File:

PDF, 425 KB

english, 1965

18

Pharmacological profile of SR 48968, a potent non-peptide antagonist of the neurokinin A (NK2) receptor

X. Emonds-Alt, C. Advenier, P. Vilain, P. Goulaouic, V. Proietto, D. Van Broeck, E. Naline, G. Neliat, G. Le Fur, J.C. Brelière

Journal:

Year:

1992

Language:

english

File:

PDF, 271 KB

english, 1992

19

SR 140333, a non-peptide antagonist of substance-P (NK1) receptor

X. Emonds-Alt, J.D. Doutremepuich, M. Jung, E. Proietto, V. Santucci, D. Van Broeck, P. Vilain, Ph. Soubrié, G. Le Fur, J.C. Brelière

Journal:

Year:

1993

Language:

english

File:

PDF, 114 KB

english, 1993

20

Neuropharmacological profile of SR 140333, a non-peptide antagonist of substance-P (NK1) receptor

M. Jung, M. Poncelet, X. Emonds-Alt, G. Le Fur, Ph. Soubrié

Journal:

Year:

1993

Language:

english

File:

PDF, 138 KB

english, 1993

21

Characterization of SR 48968 specificity for neurokinin A (NK2) receptor

P. Vilain, X. Emonds-Alt, J.C. Brelière

Journal:

Year:

1993

Language:

english

File:

PDF, 130 KB

english, 1993

22

SR 140333, a novel and potent antagonist of the NK1 receptor: Characterisation on the U373MG cell line

F. Oury-Donat, I.A. Lefevre, X. Emonds-Alt, G. Le Fur, P. Soubrie

Journal:

Year:

1993

Language:

english

File:

PDF, 138 KB

english, 1993

23

Characterization of the binding sites of [3H]SR140333, a potent non-peptide radioligand antagonist of the tachykinin NK1 receptor

X. Emonds-Alt, N. Baudry, F. Lozano, P. Pointeau, G. Le Fur, J.C. Breliere

Journal:

Year:

1994

Language:

english

File:

PDF, 129 KB

english, 1994

24

Influence of SR48968, a neurokinin NK2-receptor antagonist, on cough induced by citric acid in conscious guinea-pig

V. Girard, E. Naline, P. Vilain, X. Emonds-Alt, C. Advenier

Journal:

Year:

1994

Language:

english

File:

PDF, 133 KB

english, 1994

25

Involvement of tachykinins in the bronchospasm induced by chemicals in the guinea-pig. Inhibition by SR48968

P. Vilain, X. Emonds-Alt, C. Advenier, G. Le Fur, J.C. Breliere

Journal:

Year:

1994

Language:

english

File:

PDF, 132 KB

english, 1994

26

Role of tachykinin NK3 receptors in the release and effects of nerve growth factor in human isolated bronchi

Emmanuel Naline, Caroline Olgart Höglund, François Vincent, Xavier Emonds-Alt, Vincent Lagente, Charles Advenier, Nelly Frossard

Journal:

European Journal of Pharmacology

Year:

2007

Language:

english

File:

PDF, 471 KB

english, 2007

27

Inhibition of inflammatory cell recruitment by the tachykinin NK3-receptor antagonist, SR 142801, in a murine model of asthma

Soazig Nénan, Noëlla Germain, Vincent Lagente, Xavier Emonds-Alt, Charles Advenier, Elisabeth Boichot

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

28

Tachykinin NK3 receptor agonists induced microvascular leakage hypersensitivity in the guinea-pig airways

Samira Daoui, Abdellah Ahnaou, Emmanuel Naline, Xavier Emonds-Alt, Vincent Lagente, Charles Advenier

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 438 KB

english, 2001

29

Interleukin-1β-induced hyperresponsiveness to [Sar9,Met(O2)11]substance P in isolated human bronchi

Eric Barchasz, Emmanuel Naline, Mathieu Molimard, Joëlle Moreau, Odette Georges, Xavier Emonds-Alt, Charles Advenier

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 291 KB

english, 1999

30

Biochemical and pharmacological activities of SR 144190, a new potent non-peptide tachykinin NK2 receptor antagonist

X Emonds-Alt, C Advenier, C Cognon, T Croci, S Daoul, J.P Ducoux, M Landi, E Naline, G Neliat, M Poncelet, V Proietto, D Van Broeck, P Vilain, P Soubrié, G Le Fur, J.P Maffrand, J.C Brelière

Journal:

Year:

1997

Language:

english

File:

PDF, 975 KB

english, 1997

31

ELECTRIC DICHROISM AND BIREFRINGENCE OF DNA, CHROMATIN, AND THEIR COMPLEXES WITH CATIONIC DYES. THE STRUCTURE OF CHROMATIN

Claude Houssier, José Bontemps, Xavier Emonds-Alt, Eugène Fredericq

Journal:

Annals of the New York Academy of Sciences

Year:

1977

Language:

english

File:

PDF, 889 KB

english, 1977

32

Effects of SR 48968 on the neuropeptide gamma-induced contraction of the human isolated bronchus

Y. Qian, C. Advenier, E. Naline, JF Bellamy, X. Emonds-Alt

Journal:

Fundamental & Clinical Pharmacology

Year:

1994

Language:

english

File:

PDF, 299 KB

english, 1994

33

A Tachykinin NK3Receptor Antagonist, SR 142801 (Osanetant), Prevents Substance P-induced Bronchial Hyperreactivity in Guinea-pigs

S. Daoui, Y.-Y. Cui, V. Lagente, X. Emonds-Alt, C. Advenier

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 372 KB

english, 1997

34

Effects of 1-hydroxyethylidene-1,1 bisphosphonate and (chloro-4 phenyl) thiomethylene bisphosphonic acid (SR 41319) on the mononuclear cell factor-mediated release of neutral proteinases by articular chondrocytes and synovial cells

Xavier Emonds-Alt, Jean-Claude Brelière, Roméo Roncucci

Journal:

Biochemical Pharmacology

Year:

1985

Language:

english

File:

PDF, 682 KB

english, 1985

35

Malformin-a1 inhibits the binding of interleukin-1β (il1β) and suppresses the expression of tissue factor in human endothelial cells and monocytes

Jean-Marc Herbert, Pierre Savi, Alain Lalé, Marie-Claude Laplace, Nicole Baudry, Jean-Marie Pereillo, Xavier Emonds-Alt

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 754 KB

english, 1994

36

Influence of (±)-CP-96,345 and SR 48968 on electrical field stimulation of the isolated guinea-pig main bronchus

Corinne A.E. Martin, Emmanuel Naline, Xavier Emonds-Alt, Charles Advenier

Journal:

European Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 892 KB

english, 1992

37

The NK2 receptor antagonist SR48968 inhibits thalamic responses evoked by thermal but not mechanical nociception

Vincent Santucci, Christiane Gueudet, Xavier Emonds-Alt, Jean-Claude Brelière, Philippe Soubrié, Gérard Le Fur

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 345 KB

english, 1993

38

Inhibition of cholinergic neurotransmission in isolated guinea-pig main bronchi by SR 48968

Corinne A.E. Martin, Xavier Emonds-Alt, Charles Advenier

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 269 KB

english, 1993

39

Antitussive effect of SR 48968, a non-peptide tachykinin NK2, receptor antagonist

Charles Advenier, Valérie Girard, Emmanuel Naline, Pol Vilain, Xavier Emonds-Alt

Journal:

European Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 273 KB

english, 1993

40

SR 140333 prevents potentiation by citric acid of plasma exudation induced by histamine in airways

Keltoum Biyah, Mathieu Molimard, Xavier Emonds-Alt, Charles Advenier

Journal:

European Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 322 KB

english, 1996

41

The NK1 receptor is involved in the neurokinin-induced shape change of rabbit platelets

P. Savi, M.Cl. Laplace, G. Le Fur, X. Emonds-Alt, J.M. Herbert

Journal:

Year:

1992

Language:

english

File:

PDF, 324 KB

english, 1992

42

Neuronal nk3-receptors in guinea-pig ileum and taenia caeci: in vitro characterization by their first non-peptide antagonist, sr142801

Tiziano Crocia, Marco Landi, Xavier Emonds-Alt, Gérard Le Fur, Luciano Manara

Journal:

Year:

1995

Language:

english

File:

PDF, 535 KB

english, 1995

43

Neuropharmacological characterization of SR 140333, a non peptide antagonist of NK1 receptors

M. Jung, R. Calassi, J. Maruani, M.C. Barnouin, J. Souilhac, M. Poncelet, C. Gueudet, X. Emonds-alt, P. Soubrié, J.C. Brelière, G. Le Fur

Journal:

Neuropharmacology

Year:

1994

Language:

english

File:

PDF, 1.51 MB

english, 1994

44

Electrophysiological, behavioural and biochemical evidence for activation of brain noradrenergic systems following neurokinin receptor stimulation

M Jung, J.C Michaud, R Steinberg, M.C Barnouin, A Hayar, G Mons, J Souilhac, X Emonds-Alt, P Soubrié, G Le Fur

Journal:

Year:

1996

Language:

english

File:

PDF, 356 KB

english, 1996

45

Neurokinin A (NK2) receptor revisited with SR 48968, a potent non-peptide antagonist

C. Advenier, N. Rouissi, Q.T. Nguyen, X. Emonds-Alt, J-C. Breliere, G. Neliat, E. Naline, D. Regoli

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 434 KB

english, 1992

46

Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists

Jean-Marie Derocq, Michel Ségui, Chantal Blazy, Xavier Emonds-Alt, Gérard Le Fur, Jean-Claude Brelière, Pierre Casellas

Journal:

Year:

1996

Language:

english

File:

PDF, 477 KB

english, 1996

47

SR 142801, a tachykinin NK3 receptor antagonist, prevents β2-adrenoceptor agonist-induced hyperresponsiveness to neurokinin A in guinea-pig isolated trachea

F.M Pinto, J.-P Saulnier, C Faisy, E Naline, M Molimard, L Prieto, J.D Martin, Xavier Emonds-Alt, C Advenier, M.L Candenas

Journal:

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

48

Comparative effects of nonpeptide tachykinin receptor antagonists on experimental gut inflammation in rats and guinea-pigs

Ludmilla Mazelin, Vassilia Theodorou, Jean More, Xavier Emonds-Alt, Jean Fioramonti, Lionel Bueno

Journal:

Year:

1998

Language:

english

File:

PDF, 996 KB

english, 1998

49

Facilitation of striatal acetylcholine release by dopamine D1 receptor stimulation: involvement of enhanced nitric oxide production via neurokinin-2 receptor activation

R Steinberg, J Souilhac, D Rodier, R Alonso, X Emonds-Alt, G Le Fur, P Soubrié

Journal:

Year:

1998

Language:

english

File:

PDF, 145 KB

english, 1998

50

Intérêt des antagonistes des récepteurs des tachykinines dans la prévention de l'hyperréactivité bronchique, la toux et l'inflammation des voies aériennes

V. Lagente, E. Boichot, X. Emonds-Alt, Ch. Advenier

Journal:

Revue Française d'Allergologie et d'Immunologie Clinique

Year:

1998

File:

PDF, 904 KB

1998

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